候选药物分子的评估

成药性分析

Developability During Early Candidates Selection Period
Protein production in mammalian expression system (HEK293 or CHO)

  • In-silico analysis (critical PTM sites, pI, free cys, N-glycosylation )
  • Purification yield by ProA
  • Aggregation --- SEC-MALS
  • Hydrophilicity --- HIC-HPLC
  • Tm by DSF (Thermofluor)

2新药研发服务-候选药物分子的评估(1) 拷贝.png

案例分析


初始-DAS

PTM压力测试

表格3.png