Evaluation of candidate drug molecules

Developability Assessments

Developability During Early Candidates Selection Period
Protein production in mammalian expression system (HEK293 or CHO)

  • In-silico analysis (critical PTM sites, pI, free cys, N-glycosylation )
  • Purification yield by ProA
  • Aggregation --- SEC-MALS
  • Hydrophilicity --- HIC-HPLC
  • Tm by DSF (Thermofluor)

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Case Study


Initial-DAS

PTM Stress test

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